Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review

Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review

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The cadherin superfamily of proteins is critical for cell-cell interactions and demonstrates tissue-specific expression profiles.In cancers, disruption of read more cell-cell adhesion is frequently associated with oncogenesis and metastasis.As such, these proteins have been the targets of multiple attempts to develop novel therapeutics in malignancy.This review hiboost 4k smart link article discusses prior and current clinical trials targeting the cadherin proteins.