ONCOLOGY CLINICAL TRIALS TARGETING MEMBERS OF THE CADHERIN SUPERFAMILY: A REVIEW

The cadherin superfamily of proteins is critical for cell-cell interactions and demonstrates tissue-specific expression profiles.In cancers, disruption of read more cell-cell adhesion is frequently associated with oncogenesis and metastasis.As such, these proteins have been the targets of multiple attempts to develop novel therapeutics in malignanc

Introduction: The World Health Organization promotes a commitment to healthy aging.The autopsy is the most complete method for the study of the diseases and in the elderly deceased their health problems are evidenced.Objective: To show the particularities in ages, sex, chronic diseases, in particular malignant tumors, sepsis and causes of death fou